PJNMed |

Original Article

Volume: 13 | Issue: 1 | Published: May 18, 2023 | Pages: 17 - 19 | DOI: 10.24911/PJNMed.175-1638605076

Assessment of Molybdenum Concentration in 99Mo/99mtc Generators (PAKGEN): 6 Years Experience

Authors: Javaid Ali , Shujat Ali , Habib Ahmad , Shoab Shah , Safiullah Khan , Ashfaq Zaman , Ghufran Biradar , Muhammad Asif , Shahzad Qasim

Article Info

Authors

Javaid Ali

Larkana Institute of Nuclear Medicine & Radiotherapy (LINAR), Larkana, Pakistan

Shujat Ali

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan

Habib Ahmad

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan

Shoab Shah

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan

Safiullah Khan

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan

Ashfaq Zaman

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan

Ghufran Biradar

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan

Muhammad Asif

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan

Shahzad Qasim

Swat Institute of Nuclear Medicine, Oncology & Radiotherapy (SINOR), Swat, Pakistan.

Publication History

Received: April 26, 2022

Accepted: January 06, 2023

Published: May 18, 2023

Abstract

Background Technitium-99m (99mTc) is a widely used radioisotope for the diagnostic procedures in nuclear medicine. The radioisotope is eluted from 99Mo/99mTc generator. Ideally there should be no Molybdenum-99 (99Mo) or any other contamination; however, sometimes traces of 99Mo are co-eluted from the generator. This impurity interferes labeling of 99mTc with pharmaceuticals result in poor quality radiopharmaceutical and unnecessary exposure to patients. The purpose of this study is to assess the contamination level of 99Mo in the eluted activity of 99mTc used for the diagnostic procedures at Swat Institute of Nuclear Medicine, Oncology and Radiotherapy (SINOR), Swat Pakistan. Also the purpose is to check the integrity of the generators being transported by road, and it is a part of quality audit of PAKGEN 99Mo/99mTc generators. Methods The data was collected for 166-PAKGEN 99Mo/99mTc generators used over 6 years at SINOR. The generators were procured from Isotope Production Division (IPD), Pakistan Institute of Nuclear Science and Technology (PINSTECH), Islamabad, Pakistan. The 99Mo impurity concentration was measured for each elution with dose calibrator (Capintech Inc. CRC-25R) and canister. Results Results for most of the generators (99.4%) were within the permissible limit (0.15 μCi of 99Mo/mCi of 99mTc) as per Pakistan Nuclear Regulatory Authority (PNRA), Nuclear Regulatory Commission (NRC), and other regulatory authorities. Only one generator (0.6%) had the values out of range. Conclusion 99Mo breakthrough concentration for most of the generators was within permissible range which shows integrity of 99Mo/99mTc PAKGEN generators and approves the quality of locally prepared 99Mo/99mTc PAKGEN generators. The study replicates excellent manufacturing and quality control of PAKGEN generators which offers a confirmation of safe medical practices.

Keywords: Molybdenum Concentration, 99Mo/99mTc generator, Nuclear medicine, Image quality

Pubmed Style

Javaid Ali, Shujat Ali, Habib Ahmad, Shoab Shah, Safiullah Khan, Ashfaq Zaman, Ghufran Biradar, Muhammad Asif, Shahzad Qasim. Assessment of Molybdenum Concentration in 99Mo/99mtc Generators (PAKGEN): 6 Years Experience. PJN Med. 2023; 18 (May 2023): 17-19. doi:10.24911/PJNMed.175-1638605076

Web Style

Javaid Ali, Shujat Ali, Habib Ahmad, Shoab Shah, Safiullah Khan, Ashfaq Zaman, Ghufran Biradar, Muhammad Asif, Shahzad Qasim. Assessment of Molybdenum Concentration in 99Mo/99mtc Generators (PAKGEN): 6 Years Experience. https://www.pjnmed.epublisyst.com/articles/2038 [Access: November 08, 2025]. doi:10.24911/PJNMed.175-1638605076

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Javaid Ali, Shujat Ali, Habib Ahmad, Shoab Shah, Safiullah Khan, Ashfaq Zaman, Ghufran Biradar, Muhammad Asif, Shahzad Qasim. Assessment of Molybdenum Concentration in 99Mo/99mtc Generators (PAKGEN): 6 Years Experience. PJN Med. (2023), [cited November 08, 2025]; 18 (May 2023): 17-19. doi:10.24911/PJNMed.175-1638605076

Harvard Style

Javaid Ali, Shujat Ali, Habib Ahmad, Shoab Shah, Safiullah Khan, Ashfaq Zaman, Ghufran Biradar, Muhammad Asif, Shahzad Qasim (2023) Assessment of Molybdenum Concentration in 99Mo/99mtc Generators (PAKGEN): 6 Years Experience. PJN Med, 18 (May 2023): 17-19. doi:10.24911/PJNMed.175-1638605076

Chicago Style

Javaid Ali, Shujat Ali, Habib Ahmad, Shoab Shah, Safiullah Khan, Ashfaq Zaman, Ghufran Biradar, Muhammad Asif, Shahzad Qasim. "Assessment of Molybdenum Concentration in 99Mo/99mtc Generators (PAKGEN): 6 Years Experience." 18 (2023), 17-19. doi:10.24911/PJNMed.175-1638605076

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Javaid Ali, Shujat Ali, Habib Ahmad, Shoab Shah, Safiullah Khan, Ashfaq Zaman, Ghufran Biradar, Muhammad Asif, Shahzad Qasim (2023) Assessment of Molybdenum Concentration in 99Mo/99mtc Generators (PAKGEN): 6 Years Experience. , 18 (May 2023), 17-19. doi:10.24911/PJNMed.175-1638605076